banda transcan 2 2016ul

Title: A randomized phase II study for tertiary prevention of squamocellular cancer of head and neck (SCCHN) with a dietary intervention.

Project Coordinator:
Lisa LICITRA (Italy) Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

Project Partners:
Ana  CASTRO  (Portugal) Grupo de Estudos de Cancro da Cabeça e Pescoço, Lisbon
Wojciech GOLUSINSKI (Poland) The Great Poland Cancer Centre, Poznań
Andreas DIETZ (Germany) University of Leipzig, Leipzig
Primož STROJAN (Slovenia) Institute of Oncology, Ljubljana
Thorsten  FUREDER (Austria) Medical University Vienna, Vienna

Project Abstract:
Survival rate for patients with locally advanced high risk Head and Neck Squamous Cell Cancer (HNSCC) is not substantially improved in the last years and it remains unsatisfactory, despite the introduction of new therapeutic strategies. There is a strong need for effective preventive approaches to reduce incidence of recurrences, second tumors and treatment related late sequelae. In epidemiological studies, diet is reported to play a major role as risk factor for HNSCC development and in a large prospective study index-based dietary patterns showed an inverse relationship with the development of HNSCC.
A specific dietary intervention as a cheap and non toxic method, widely and easily affordable in all EU countries, and the identification of reliable biomarkers that may improve its efficiency constitute the basis of this project. In one year prospective randomized trial, 350 effectively cured, stage III-IV HNSCC survivors from 6 different countries will be enrolled. The study includes 2 intervention arms: an experimental arm, with a highly monitored and specific dietary intervention based on AICR/WCRF recommendations for cancer prevention and a control arm based on standard recommendations. Clinical endpoints are: incidence reduction of tumor recurrence and second primaries; improvement of quality of life in HNSCC survivors. Translational endpoints are: miRNAs identification and their changes in saliva and blood; identification of cytokine and growth factors in blood and inflammatory cytokine profile changes; time course of saliva monitoring of DNA methylation.

(Project funded under JTC 2013)


Launch of the call: JTC 2021
The new TRANSCAN-3 project consortium is launching the first Joint Transnational Call for proposals, co-funded by the European Commission, on:
"Next generation cancer immunotherapy: targeting the tumour microenvironment"

International Networking Event (virtual)
on 22 April 2021 hrs 9:00 CET
will focus on the forthcoming co-funded JTC 2021 on:
"Next generation cancer immunotherapy: targeting the tumour microenvironment" 
the event is organized by TUBITAK under the “Turkey in Horizon 2020 Phase II” Technical Assistance Project
in cooperation with TRANSCAN-3

 Sustained collaboration of national and regional programmes in cancer research
is the new project funded by the European Commission under H2020  which started on 1st March 2021 and will last five years (G. A. no. 964264)

A TRANSCAN-2 brochure, highlighting key achievements, is available for download


eu flagship

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 643638.

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