banda transcan 2 2016ul

Title: A TranslatiOnal Platform for de-orphaning malignant pleural MESOthelioma

Project Coordinator:
Federico Bussolino (Italy), Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO) - IRCCS, Head Laboratory of Vascular Oncology, Candiolo (Torino)

Project Partners:
Luis Paz-Ares (Spain), Hospital Universitario 12 de Octubre, Chair Medical Oncology, Madrid
Paul Baas (Netherlands), Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AVL), Thoracic Oncology, Amsterdam

Project Abstract:
Unmet needs in malignat pleural mesothelioma (MPM) are the lack of early detection strategies, the intrinsic chemoresistance, the lack of biomarkers for experimental and innovative therapeutic strategies,including angiogenesis and immune modulators. The consortium has set-up a robust living biobank of MPM to explore therapeutic strategies to de-orphan MPM pathogenesis, including primary cultures, patient-derived xenografts (PDXs) and innovative 3D-immune-organoids. We hypothesize that the above biobank as well as tissue and liquid biopsies will serve as a prerequisite to lead an unprecedented multi-tasking functional effort and identify actionable pathways, therapeutic strategies and predictive biomarkers.
Aims: 1)To molecularly annotate living MPM preclinical models and patient samples (WP1,WP2, WP3,WP8); 2)To perform functional and pharmacogenomics screens in MPM preclinical models in order prioritize combination therapies for clinical testing (WP4, WP5, WP6); 3)To identify candidate predictive and prognostic biomarkers in MPM patients treated with immunotherapy and/or anti-angiogenic therapy (all WPs).
Methods: pre-existing MPM models and those generated in WP2 following approval of a joint biobanking protocol(WP1) will be subjected to –omics analyses (WP3). Drugs (WP4) and genome-wide Crispr/Cas9 libraries(WP5) will be screened in primary MPM cultures and hits validated in PDXs. Immunoorganoids will be tested ex vivo with immunotherapy and angiogenesis modulators(WP6). Selected markers from WP3 and WP6 will be tested in liquid biopsies from MPM patients treated with anti-angiogenic or immune-based therapies (WP7). Bioinformatics(WP8), data integration(WP9), and project management strategies(WP10) are in place. This project will couple molecular profiling to functional characterization of MPM models. Novel therapeutic strategies suitable for clinical testing and minimally invasive biomarkers could result in better patient management and outcome.

 

(Project funded under JTC 2017)


TRANSCAN News

Launch of the call: JTC 2021
The new TRANSCAN-3 project consortium is launching the first Joint Transnational Call for proposals, co-funded by the European Commission, on:
"Next generation cancer immunotherapy: targeting the tumour microenvironment"

International Networking Event (virtual)
on 22 April 2021 hrs 9:00 CET
will focus on the forthcoming co-funded JTC 2021 on:
"Next generation cancer immunotherapy: targeting the tumour microenvironment" 
the event is organized by TUBITAK under the “Turkey in Horizon 2020 Phase II” Technical Assistance Project
in cooperation with TRANSCAN-3

ERA-NET Cofund TRANSCAN-3:
 Sustained collaboration of national and regional programmes in cancer research
is the new project funded by the European Commission under H2020  which started on 1st March 2021 and will last five years (G. A. no. 964264)

A TRANSCAN-2 brochure, highlighting key achievements, is available for download

 

eu flagship

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 643638.

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