Projects funded under JTC 2017 on: "Translational research on rare cancers"
Acronym
Title
Harnessing BRCAness as a therapeutic target in high-risk pediatric solid tumors
Implementation of (epi)genetic and metabolic networks in the targeting of T-cell prolymphocytic leukemia
An integrated European platform to conduct translational studies in myelodysplastic syndromes based on the EuroBloodNet infrastructure
Translational Research in Peripheral T-Cell Lymphomas: from characterization to novel targets
Advancing liquid biopsies for monitoring and personalized treatment of children with neuroblastomas
Comprehensive genomic characterization of upper urinary tract urothelial carcinoma and paired bladder recurrences
Establishing an algorithm for the early diagnosis and follow-up of patients with pancreatic neuroendocrine tumors
Predictive models of therapy response in pancreatic neuroendocrine tumors
Profiling radioREsistant Differentiated thyroid Cancer: genes, immunity, cancer stem cells and epithelial-mesenchymal transition
Automated, absolute quantification of MRD in ALL patients by droplet microfluidics, single DNA copy barcoding and IG/TR amplicon NGS
Anti-PD1 and Niraparib (PARPi) combination therapy in gynae carcinosarcoma: Identification of response-predictive biomarkers and resistance mechanisms
Projects funded under JTC 2016 on: "Minimally and non-invasive methods for early detection and/or progression of cancer"
Acronym
Title
Airborne biomarkers for colorectal cancers
Biomarkers for diagnosis and prognosis of endometrial carcinoma
Validation of multiparametric models and Circulating and imaging biomarkers to improve Lung cancer EARLY detection
Detection of early esophageal cancer by near-infrared fluorescence molecular endoscopy
Multi-parametric analysis of the evolution and progression of low grade glioma
Single-cell immunophenotypic and transcriptomic profiling for minimally-invasive detection of early multiple myeloma
New strategies to detect cancers in carriers of mutations in RB1: blood tests based on tumor-educated platelets, or extracellular vesicles
Employing NGS technology for improved, non-invasive early detection, staging and prediction of progression in lymphoma patients
Early detection of prostate cancer by liquid biopsies
Exploitation of extracellular vesicles for precision diagnostics of prostate cancer
Non-invasive prognostic markers for Resected Early-STage NSCLC: role of circulatING and exosomal miRNAs and free circulating DNA
Microbiota-based SCReening of Anal Cancer in HIV-infected individuals
Early detection of relapses in stage III colon cancer patients by longitudinally following a personalized molecular signature from a a blood test: THRuST
Integration of genetic biomarkers and early minimal residual disease to improve risk stratification and cure in childhood Acute Lymphoblastic Leukemia
Projects funded under JTC 2015 on: "Immunology and immunotherapy of cancer: strengthening the translational aspects"
Acronym
Title
Impact of dietary intervention on tumor immunity
Dual epigenetic targeting and immunotherapy to fight against cancer
Mutated neo-antigens in hepatocellular carcinoma
Deciphering immune response against glioblastoma to find new targets
Targeting sphingolipid metabolism to improve anti-melanoma immunotherapy
Improving immunotherapy of solid tumors by targeting the immunosuppressive tumor microenvironment: from pre-clinical "proof-of-concept" to the development of phase Ib study
Prediction of nivolumab action in metastatic renal cancer patients:Treg function, tumoral access and NK interactions as predictive biomarkers of immunotherapy
Projects funded under JTC 2014 (EC co-funded call) on: "Translational research on human tumour heterogeneity to overcome recurrence and resistance to therapy"
Acronym
Title
Approaching recurrence and resistance mechanisms in esophagogastric adenocarcinomas from the prospective MEMORI trial
Patient‐derived models for intratumour functional heterogeneity and its implications for personalized medicine
Clinical impact of intratumor heterogeneity in metastatic breast cancer
Cancer evolution and identification of relapse-initiating cells
Defeating Recurrence and resistance in AML:Multigenomic Approaches to analyse heterogeneity
Fighting Resistance in CLL
Genetic and cellular intratumor heterogeneity as predictor of chronic lymphocytic leukemia outcome and treatment resistance
Intratumour heterogeneity, clonal selection and metastatic propensity in breast cancer
Evolution of resistant clones to novel target-directed drugs in colorectal tumors. A genetic and epigenetic study of intratumoral heterogeneity dynamics
Multiple myeloma intra-clonal heterogeneity: evolution and implications of targeted therapy
Dissecting phenotypic heterogeneity of human melanoma: building a rationale for active immunotherapies overcoming immunologically-induced dedifferentiation
Overcoming Neuroblastoma Tumour HETerogeneity, Resistance and RecurrAnCe
Proteogenomic and targeted metabolomic analysis of ovarian cancer heterogeneity and its contribution to recurrence and therapy resistance
TArgeting Colon Tumor Initiating Cell heterogeneity
Clinical utility of tumour heterogeneity in triple negative breast cancer and high-grade serous ovarian carcinoma for prediction of therapy response
Targeting Of Resistance in PEDiatric Oncology
Projects funded under JTC 2013 on: "Translational research on tertiary prevention in cancer patients"
Acronym
Title
A randomized, 2x2 biomarker prevention trial of low-dose aspirin and metformin in colon cancer patients
Exploiting the peptidome of atypical teratoid/rhabdoid tumors - characterization of novel tumor-associated antigens for immunotherapy in order to maintain long-term remissions
MicroRNAs methylation and expression profiling for identification of breast cancer patients at high risk to develop distant metastases
A randomized phase II study for tertiary prevention of squamocellular cancer of head and neck (SCCHN) with a dietary intervention
Biomarkers related to folate-dependent one-carbon metabolism in CRC recurrence and survival
Identification of genetic markers involved in development of metastases and second cancers in melanoma
High resolution project on prognosis and CARE of cancer patients
Integrative cancer-immunology and Immunoscore for cancer classification and immunotherapies
A randomized placebo controlled phase II study with Metformin in metabolic-unbalanced breast cancer survivors at higher risk for recurrence
Projects funded under JTC 2012 on: “Translational research on primary and secondary prevention of cancer”
Acronym
Title
An integrated approach for epigenetic risk assessment and biomarker development for breast cancer in prospective cohorts / Identifying early epigenetic predictors of breast cancer risk and their etiology determinants
Cancer prevention through improved familial risk assessment and gene discovery
New technologies for early detection of HLA loss leukemia relapse after allogeneic hematopoietic stem cell transplantation, and identification of relevant risk factors
Identification of molecular therapeutic targets and diagnostic/prognostic biomarkers for Malignant Transformation of Osteochondromas
Mesalamine for Colorectal Cancer Prevention Program in Lynch syndrome
Metabolomic profiles throughout the continuum of colorectal cancer
Nanoparticle-Enhanced molecular Fluorescence-Endoscopy for detection of early-stage colorectal adenocarcinomas
Personalized prevention of colorectal neoplasia by use of genetic variability for the prediction of efficacy and toxicity of treatment with COX-2 inhibitors and aspirin
Development of a Comprehensive Risk Prediction Model for BRCA1 and BRCA2 mutation carriers
TRanslational Implementation of Genetic Evidence in the management of MDS
Projects funded under JTC 2011 on: "Validation of biomarkers for personalised cancer medicine"
Acronym
Title
K-RAS mutations and DNA repair function in NSCLC
Circulating Tumor Cells as Biomarker for Minimal Residual Disease in Prostate Cancer
Early prediction of efficacy of endocrine therapy in breast cancer: pilot study and validation with 18F Fluoroestradiol (FES) PET/CT
Phase I clinical trial using a novel CCK-2/gastrin receptor-localizing radiolabelled peptide probe for personalized diagnosis and therapy of patiens with progressive or metastatic medullary thyroid carcinoma
Validation of immune biomarkers predictive of clinical outcome after HLA-haploidentical hematopoietic stem cell transplantation for acute leukemia
Immune Cells as Predictors for Early Diagnosis and Chemotherapy Toxicity in Ovarian Cancer
PROspective VAlidation of Biomarkers in Ewing Sarcoma for personalised translational medicine
Validation of the impact of genetic aberrations and host genetic variation in childhood acute lymphoblastic leukemia for integration into clinical practice
CD3 and CD20 lymphocytes infiltration to predict chemosensitivity in patients with triple negative breast cancer
Validation of Aprataxin as a biomarker of response to Topoisomerase I inhibitors in cancer patient
